Hemostasis is the process of stopping bleeding from a damaged blood vessel. When bleeding occurs, the body will naturally respond with a hemostatic mechanism to stop the bleeding. Indonesian people have long used plants in medicine, one of which is sambang darah (Excoecaria cochinchinensis L) plant. Sambang darah has a chemical compound that is thought to stop bleeding. The purpose of this study was to determine the potential of sambang darah filtrate to reduce the bleeding time in skin wounds of white rats (Rattus norvegicus). This study is a pre-experimental study with a static group comparison approach. The number of experimental units in this study were 10 white rats which were divided into treatment group and control group. Data analysis used the Independent Sample T Test. The results showed that the average of bleeding time in the skin wounds of white rats without drops of sambang darah leaf filtrate was 252 seconds. While the average of bleeding time in the skin wounds of white rats with drops of sambang darah leaf filtrate is 163 seconds. The conclusion of this study is sambang darah (Excoecaria cochinchinensis L) leaf filtrate have a potential to reduce the bleeding time in the skin wounds of white rats (Rattus norvegicus). 

Gaib, L. A., Rahayu, M., & Sukeksi, A. (2019). Effect of Dried Gedi Leaf Extract (Abelmoschus manihot L. Medik) on Blood Clotting Time In Vitro Using Method Modification of Lee and White. Prosiding Seminar Mahasiswa Unimus, 238–242.

Kainde, A. R., Pangemanan, D. H. C., & Hutagalung, B. S. P. (2016). Test the effectiveness of spoon leaf extract (Plantago major L.) on bleeding time in male Wistar rats (Rattus norvegicus). E-GIGI, 4(2).

Oktariza, S., Ma’ruf, Y., & Etika, S. B. (2013). Isolation and Characterization of Flavonoids from Blood Leaves (Excoecaria chochinchinensis L). Chemistry Journal of State University of Padang, 2(2), 22–27.

Pradhan, D., Suri, K. a, Pradhan, D. K., & Biswasroy, P. (2013). Golden Heart of the Nature : Piper betle L . Journal of Pharmacognosy and Phytochemistry, 1(6), 147–167.

Putu, N., Asri, W., Pratini, P., Anggit Jiwantoro, Y., Khusuma, A., Jurusan, A., Kesehatan, K., & Mataram, I. (2019). Perbedaan Kadar Kolesterol Total Menggunakan Antikoagulan EDTA (CH 2 CO 2 H), Natrium Sitrat (Na 3 C 6 H 5 O 7 ), dan Natrium Oksalat (Na 2 C 2 O4). Jurnal Analis Medika Biosain (JAMBS), 6(2), 130–134.

Puzi, W. S., Lukmayani, Y., & Dasuki, U. A. (2015). Isolation and Identification of Flavonoid Compounds from Red Betel Leaf (Piper crocatum Ruiz & Pav). Prosiding Penelitian SPeSIA Unisba, 9(April), 17–26.

Sembiring, I. C. B., Wardhita, A. A. G., & Adi, A. A. A. M. (2021). Muntingia Calabura’S Leaves Extract Ointment Increased Collagen Density and Enhanced Healing of Skin Incision Wound in Hyperglycemic Mice. Indonesia Medicus Veterinus, 10(2), 189–199.

Setiawan, A. (2022). Indonesian Biodiversity: Problems and Its Conservation Efforts. Indonesian Journal of Conservation, 11(1), 13–21.

Sidrotullah, M. S. (2021). Effect Of Bleeding Time Of Bandotan Leaves (Ageratum conyzoides L.) IN MICE (Mus musculus). Journal Syifa Sciences and Clinical Research, 3(1), 37–44.

Susilawati, E. (2015). Potential of Talas stem sap (Colocasia esculenta (L.) Schott) in the process of stopping bleeding in skin lesions of white rat (Mus musculus).

Tedjasulaksana, & Regina. (2013). Ethyl Acetate and Ethanol Extracts of Betel Leaf (Piper betle L.) can Shorten the Bleeding Time of Mice (Mus musculus). Jurnal Kesehatan Gigi, 1(1), 33.

Zega, S. (2013). Isolation of Flavonoids from Blood Leaves (Excoecaria chochinchi_nen-sis L).