Relationship of Leukocyte and Platelet Counts with NS-1 Antigen Examination Results in Suspected Dengue Fever Patients
Keywords:
Leukocyte count, Platelet count, NS-1, Dengue fever suspectAbstract
Dengue fever is still a global health problem, with high mortality rates due to dengue fever. Leukopenia and thrombocytopenia often occurs in dengue fever patients. Early detection of dengue virus infection through dengue NS-1 is needed to avoid delays in diagnosis where NS-1 has high sensitivity in detecting dengue virus infection in the early phase. A decrease in the number of leukocytes and platelets is a finding that can provide an indication of the severity of the disease and assist in the diagnosis of DHF. The aim of this research was to establish the relationship between total platelet and leukocyte counts and NS-1 antigen assay findings in individuals with suspected hemolytic disease of the liver (HDL). The research was quantitative, with an observational design and a cross-sectional approach. The study population consisted of 91 patients with suspected HDL at the Mayong II Jepara Health Center between January and December 2024. Total sampling was used. The findings indicated that males were the predominant group of patients with suspected HDL, and that 62% of them were in the 0-5 year age group. The average number of leukocytes in patients was 12,457 ± 3,471 cells/mm3 of blood with the lowest leukocyte count of 3,400 cells/mm3 and the highest 20,500 cells/mm3. The average number of platelets was 162,626 ± 72,930 cells/mm3 of blood with the lowest platelet count of 54,000 cells/mm3 and the highest 385,000 cells/mm3. The results of the NS-1 examination of suspected DHF patients were 69% positive and 31% negative. There was no relationship between the number of leukocytes and the NS-1 antigen examination (p value 0.220>0.05) but there was a relationship between the number of platelets and the NS-1 antigen examination (p value 0.00<0.05) in suspected DHF patients at Mayong II Jepara Health Center.
References
A. Joshi, A., B. R., G., & Gowda R., Y. (2017). The total leucocyte count: its utility in dengue. International Journal of Advances in Medicine, 4(6), 1621. https://doi.org/10.18203/2349-3933.ijam20175178
Aeni, F. N., & Saptaningtyas, R. (2023). Gambaran Jumlah Leukosit Pada Pasien Anak Demam Tifoid di RSD K.R.M.T Wongsonegoro Kota Semarang. Prosiding Seminar Nasional UNIMUS, 6, 571. https://prosiding.unimus.ac.id/index.php/semnas/article/viewFile/1545/1548
Alamlih, L., Albakri, M., Ibrahim, W. H., Khan, A., & Khan, F. Y. (2020). Hematologic Characteristics of Patients with Active Pulmonary, Extra-Pulmonary and Disseminated Tuberculosis: A Study of over Six Hundred Patients. Journal of Tuberculosis Research, 08(02), 33–41. https://doi.org/10.4236/jtr.2020.82004
Ashary, R., Ferlianti, R., & Riani, S. N. (2024). Gambaran Kasus Demam Berdarah Dengue (DBD) Berdasarkan Jenis Kelamin Anak di RSUD Dr. Drajat Prawiranegara Serang pada Tahun 2021. Junior Medical Journal, 2(6), 715–722.
Candra, A. (2016). Demam Berdarah Dengue: Epidemiologi, Patogenesis, dan Faktor Risiko Penularan. Aspirator, 2(2), 110–119. https://doi.org/https://dx.doi.org/10.22435/aspirator.v2i2.2951.
De Simone, B., Davies, J., Chouillard, E., Di Saverio, S., Hoentjen, F., Tarasconi, A., Sartelli, M., Biffl, W. L., Ansaloni, L., Coccolini, F., Chiarugi, M., De’Angelis, N., Moore, E. E., Kluger, Y., Abu-Zidan, F., Sakakushev, B., Coimbra, R., Celentano, V., Wani, I., … Catena, F. (2021). WSES-AAST guidelines: management of inflammatory bowel disease in the emergency setting. World Journal of Emergency Surgery, 16(1), 1–27. https://doi.org/10.1186/s13017-021-00362-3
Devina, Rimbun, S., & Situmeang, I. (2022). Hubungan Perbandingan Penurunan Trombosit Dan Leukosit Pada Penyakit DBD Pada Anak-Anak. Jurnal Kedokteran Methodist, 15(1). https://ejurnal.methodist.ac.id/index.php/jkm/article/view/1594
Dinkes Kabupaten Jepara. (2023). Profil Kesehatan Kabupaten Jepara (S. P. D. K. Jepara (ed.)).
Dinkes Kabupaten Jepara. (2024). Hasil Rapat Koordinasi DBD: Analisis Situasi Demam Berdarah Dengue kabupaten Jepara tanggal 24 Februari 2024 di Dinas Kesehatan Kabupaten Jepara.
Dinkes Prov Jateng. (2023). Profil Kesehatan Jawa Tengah 2023.
Efiariza, N. N., Pertiwi, D., Permana, H., Efrida, Yerizel, E., Les, & Tari, R. (2023). Hubungan Nilai Hematokrit, Jumlah Trombosit Dan Jumlah Leukosit Dengan Derajat Klinis Pasien Demam Berdarah Dengue Anak Di Rsup Dr. M. Djamil Padang. SENTRI: Jurnal Riset Ilmiah, 2(4), 1275--1289. https://ejournal.nusantaraglobal.or.id/index.php/sentri/article/view/3506/3426
Hidayat, W. A., Yaswir, R., & Murni, A. W. (2017). Hubungan Jumlah Trombosit dengan Nilai Hematokrit pada Penderita Demam Berdarah Dengue dengan Manifestasi Perdarahan Spontan di RSUP Dr. M. Djamil Padang. Jurnal Kesehatan Andalas, 6(2), 446. https://doi.org/10.25077/jka.v6i2.719
Hidayatullah, M. A. A. M., & Aisyah, R. (2018). Hubungan Jumlah Trombosit Dengan Jumlah Eritrosit Pada Pasien Infeksi Virus Dengue Di Rs X Surakarta. Biomedika, 9(2), 65–70. https://doi.org/10.23917/biomedika.v9i2.5846
Hikma, F., Ridwan, A., & Asdinar. (2023). Gambaran Pemeriksaan Jumlah dan Jenis Leukosit Pada Pasien Infeksi Saluran Pernapasan Akut (ISPA) di RSUD H. Andi SUltan Daeng Radja Kabupaten Bulukumba Tahun 2021. Journal of Global and Multidisciplinary, 1(5), 655–663.
Huy, B. V., & Toà n, N. V. (2022). Prognostic indicators associated with progresses of severe dengue. PLoS ONE, 17(1 January), 1–11. https://doi.org/10.1371/journal.pone.0262096
Ikrima, I., Buchari, B., & Hidayat, R. (2017). Pengaruh Kadar Hematokrit Terhadap Derajat Klinis Demam Berdarah Dengue pada Pasien Anak Ruang Rawat Inap di Rumah Sakit Umum Daerah Zainoel Abidin Banda Aceh. Jurnal Ilmiah Mahasiswa Medisia, 2(4).
Kemenkes RI. (2022). Membuka Lembaran Baru Untuk Hidup Sejahtera. Laporan Tahunan 2022 Demam Berdarah Dengue, 17–19.
Kemenkes RI. (2024). Profil Kesehatan Indonesia 2023 (K. K. R. Indonesia (ed.)). Kementerian Kesehatan Republik Indonesia.
Marsudi, L. O., Irwadi, D., & Sumbung, A. (2022). Hasil pemeriksaan hematologi rutin pada pasien Demam Berdarah Dengue (DBD): sebuah studi literatur. Jurnal Teknologi Laboratorium Medik Borneo, 2(1), 62–68. https://jurnal.itkeswhs.ac.id/index.php/mlt/article/view/1072
Masihor, J. J. G., Mantik, M. F. J., Memah, M., & Mongan, A. E. (2013). Hubungan Jumlah Trombosit Dan Jumlah Leukosit Pada Pasien Anak Demam Berdarah Dengue. Jurnal E-Biomedik, 1(1). https://doi.org/10.35790/ebm.1.1.2013.4152
Maulin, K. N., & Irma, F. A. (2023). Hubungan Jumlah Trombosit Dan Hematokrit Dengan Derajat Keparahan Demam Berdarah Dengue Di Rsud Dr. Pirngadi Kota Medan Tahun 2019-2021. Jurnal Implementasi Husada, 4(4), 288–298.
Paizer, D., Sidiq, A. N., Ardila, D., & Sripratiwi, C. (2024). Hubungan Jumlah Trombosit dan Jumlah Leukosit pada Pasien Demam Berdarah Dengue (DBD). Jurnal Pengabdian Kepada Masyarakat (JPKM) - Aphelion, 6(4), 171–178. https://jurnal.globalhealthsciencegroup.com/index.php/JPM/article/view/2494
Raihan, R., Malo, R., Jewel, Y. M., Ferdousy, F. A., Abul, S., Abdullah, H., Munshi, S. U., Jahidur, M., & Khan, R. (2025). NS1 Rapid Card Test for Dengue Detection : Insights from the 2023 Outbreak in Bangladesh. International Journal of General Medicine, 18, 2047–2056.
Rao, A. S., Pai, B. H. K., Adithi, K., Keshav, L. B., Malhotra, K., Nayak, S., & Sachidananda, H. K. (2024). Scoring model for exploring factors influencing mortality in dengue patients at a tertiary care hospital: a retrospective study. In Discover Applied Sciences (Vol. 6, Issue 12). Springer International Publishing. https://doi.org/10.1007/s42452-024-06302-5
Rosyanti, L., & Hadi, I. (2020). Respon Imunitas Dan Badai Sitokin Severe Acute Respiratory Syndrome Corona Virus 2 Literatur Review. Jurnal Kesehatan Madani Medika, 11(02), 176–201.
Santosa, B. (2020). Antigen Non Struktural 1 (Ns1) Sebagai Marker Suspek Infeksi Dengue. Jurnal Media Analis Kesehatan, 11(1), 27. https://doi.org/10.32382/mak.v11i1.1476
Sari, N. W. A. A., & Yasa, I. W. P. S. (2020). Hubungan Antara Uji Antigen Non Structural 1 (NS1) Dengan Kejadian Trombositopenia Pada Kasus Demam Dengue (DD)/Demam Berdarah Dengue (DBD) Dirumah Sakit Ari Canti, Gianyar, Bali Tahun 2016. Jurnal Medika Udayana, 9(6), 79–83. https://doi.org/https://doi.org/10.24843/MU.2020.V09.i6.P15.
Sari, R. N., Natalia, D., & Parinding, J. T. (2020). Hubungan Lama Demam dengan Hasil Pemeriksaan Antigen Nonstruktural 1 Dengue pada Pasien Demam Berdarah Dengue di RSUD Sultan Syarif Mohamad Alkadrie Tahun 2018. Jurnal Biomedik:JBM, 12(3), 153. https://doi.org/10.35790/jbm.12.3.2020.31186
Syafutra, W., Almurdi, A., & Syah, N. A. (2022). Hubungan Jumlah Leukosit dengan Trombosit pada Infeksi Dengue Primer dan Dengue Sekunder. Jurnal Ilmu Kesehatan Indonesia, 2(3), 127–134. https://doi.org/http://dx.doi.org/10.25077/jikesi.v2i3.326
Widarti, W., Kalma, K., Herman, H., & Ramadhani, A. F. (2023). Analisis Jumlah Trombosit Dan Leukosit Pada Pasien Dengue Hemorrhagic Fever (DHF) Di Rumah Sakit Umum Daerah Kabupaten Barru. Jaringan Laboratorium Medis, 5(2), 95–103. https://doi.org/10.31983/jlm.v5i2.9964
Wila, R. W., & Nusa, R. (2020). Gambaran Klinis dan Respon Imun Penderita Demam Berdarah Dengue di Rumah Sakit Kristen Lindi Mara Sumba Timur. Balaba: Jurnal Litbang Pengendalian Penyakit, 16(2), 209–216. https://doi.org/http://dx.doi.org/10.22435/blb.v16i2.2816
Wulandari, M. F., Hadi, S., & Eka Putri, D. (2023). Hubungan Jumlah Leukosit Terhadap Hasil Pemeriksaan NS-1 Pasien Suspek DBD. Binawan Student Journal, 5(1), 1–7. https://doi.org/10.54771/bsj.v5i1.675
Yanuar, S., Indonesia, U., & Sinto, R. (2024). Peningkatan Leukosit, Neutrofil, dan Prokalsitonin Persisten Tanpa Bukti Infeksi pada Kanker Stadium Akhir: Sebuah Laporan Kasus. Jurnal Penyakit Dalam Indonesia, 11(1). https://doi.org/10.7454/jpdi.v11i2.1558
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