Analysis of the Effect of Taking Anti-Tuberculosis Drugs (ATD) on Blood Glucose Levels and Urine Protein Levels in Tuberculosis Sufferers at the Dasan Tapen Community Health Center, West Lombok

Authors

  • Leni Wahyuni Politeknik Kesehatan Kementerian Kesehatan Mataram, Indonesia
  • Agrijanti Agrijanti Politeknik Kesehatan Kementerian Kesehatan Mataram, Indonesia
  • Lalu Srigede Politeknik Kesehatan Kementerian Kesehatan Mataram, Indonesia

DOI:

https://doi.org/10.32807/jambs.v11i2.354

Keywords:

Anti-Tuberculosis Drugs, Blood glucose, Urine protein

Abstract

Tuberculosis is a contagious infectious disease caused by the bacteria Mycobacterium tuberculosis or often called Acid-Fast Bacteria (AFC). Tuberculosis positive patients must undergo treatment by administering category 1 Anti-Tuberculosis Drugs (ATD) for approximately 6-8 months. Anti-Tuberculosis Drugs (ATD) are divided into two phases, namely the intensive phase and the advanced phase. Consuming Anti-Tuberculosis Drugs (ATD) for a long period of time can cause the drug to become toxic in the body, so that it can affect body organs such as the kidneys and pancreas. The aim of this study was to measure blood glucose levels, measure urine protein levels and analyze blood glucose levels and urine protein levels in tuberculosis sufferers who took Anti-Tuberculosis Drugs (ATD). Using analytical observational research methods with a cross sectional research design . Tuberculosis sufferers are checked for blood glucose and urine protein, first and second collection. The results of research on 24 tuberculosis patients who took Anti-Tuberculosis Drugs (ATD) at the Dasan Tapen Community Health Center, West Lombok showed that the blood glucose levels of tuberculosis patients who took intensive phase ATD, namely of the 14 patients, 9 patients experienced an increase. Meanwhile, in the continuation phase, of the 10 patients, there were 6 patients who experienced improvement. The urine protein levels of tuberculosis sufferers who consumed ATD in the intensive and follow-up phase of the first examination were positive (+1) in 1 sample while negative (-) in 23 samples. In the second examination, 2 samples were positive (+1), while 22 samples were negative (-). The conclusion of this study is that there is no relationship between the first and second examination of random blood glucose levels and random urine protein levels.

References

Al-Naimi M, Rasheed H, Hussien N, Al-Kuraishy H, Al-Gareeb A. Nephrotoxicity: Role and significance of renal biomarkers in the early detection of acute renal injury. J Adv Pharm Technol Res. 2019;10(3):95.

Brereton, M. F., Rohm, M., Shimomura, K., Holland, C., Babeay, S. T., Dadon, D., Iberl, M., Chibalina, M. v., Lee, S., Glaser, B., Dor, Y., Rorsman, P.,C Clark, A., Ashcroft, F. M. (2016). Hyperglycaemia Induces Metabolic Dysfunction and Glycogen Accumulation in Pancreatic B-Cells. National Library of Medicine

Cordova, D. M., Aulia, S., Darmawan, N., Alfiyah, M., Utami, M. R., & Nurfadhila, L. (2023). Metode Analisis Obat Tuberkulosis Dalam Plasma Darah. Journal of Pharmaceutical and Sciences (Volume 6)

Harries AD, Murray MB, Jeon CY, Ottmani SE, Lonnroth K, Barreto ML dkk. Menetapkan Agenda Penelitian Untuk Mengurangi Beban Sendi Penyakit Diabetes Melitus Dan Tuberkulosis . Pengobatan Tropis & Kesehatan Internasional: TM & IH . 2010; 15 ( 6 ):659–63

Jiwantoro, D. Anggraeni.(2023). Metodologi Penelitian dan Statistik Kesehatan (Untuk Jurusan Teknik Laboratorium Medis). Jakarta: TIM.

Kemenkes. (2011). Pedoman Interpretasi Data Klinik. Kementerian Kesehatan RI. Jakarta: Kementerian Kesehatan RI. 52–56 p.

Mursyaf, N. A. S., Nurdiyanah, & Ibrahim, H. (2018). Keberhasilan Pengobatan Tuberkulosis (TB) Paru Diwilayah Kerja Puskesmas Panambungan Kota Makassar. Higiene, 4(4), 33-40

Nufus, H., Getas, W., & Jiwantoro, Y. A. (2023). Analisis Protein Urine Pada Penderita Tuberkulosis Yang Mengonsumsi Obat Anti Tuberkulosis (OAT) Fase Intensif dan Fase Lanjutan di Puskesmas Sengkol, Lombok Tengah. In Jurnal Analis Medika Biosains (JAMBS). http://jambs.poltekkes-mataram.ac.id/index.php/home

Pratama, A. (2021). Gambaran Kadar Darah Glukosa Pada Penderita Tuberkulosis Paru Sebelum Dan Sesudah Terapi Obat Anti Tuberkulosis (OAT). Karya Tulis Ilmiah.

Pratiwi, E. P., Rohmawaty, E., & Kulsum, I. D. (2018). Efek Samping Obat Anti Tuberkulosis Kategori I dan II Pasien Tuberkolosis Paru Dewasa di Rumah Sakit Hasan Sadikin. Indonesian Journal of Clinical Pharmacy, 7(4), 252. https://doi.org/10.15416/ijcp.2018.7.4.252

Sons. Blandy’s Urology. 3rd ed. Aboumarzouk OM, editor.Wiley; 2019. 117–120 p.

Downloads

Additional Files

Published

2024-10-31

How to Cite

Wahyuni, L., Agrijanti, A., & Srigede, L. (2024). Analysis of the Effect of Taking Anti-Tuberculosis Drugs (ATD) on Blood Glucose Levels and Urine Protein Levels in Tuberculosis Sufferers at the Dasan Tapen Community Health Center, West Lombok. Jurnal Analis Medika Biosains (JAMBS), 11(2), 79–84. https://doi.org/10.32807/jambs.v11i2.354

Citation Check