Correlation of Leukocyte Esterase Positivity Levels Against the Results of Several Examination Parameters Laboratory Urinary Tract Infection in Patients at Mataram City Regional Hospital

Abstract

Background : Urinary tract infection (UTI) is caused by the
multiplication of bacteria in the urinary tract. The standard proving
procedures for UTI are urine culture examination and urine dipstick
examination (leukocyte esterase and nitrite). Objective : This study
aims to measure leukocyte and nitrite values, calculate the total
number of bacteria, identify Gram type, species and antibiotic
sensitivity and analyze the correlation of leukocyte esterase positivity
to the results of several UTI examination parameters. Research
Methods : The method used is an analytic observational design with
cross sectional design using primary data and analyzed with the
Spearman rank test. Results : The results showed that in 198 patients
with suspected UTI, 123 (62%) were positive for leukocyte esterase,
16 (8.1%) were positive for nitrite. The total number of bacterial count
showed 82 people (41%) with bacteriuria ≥10 5 CFU/mL. Found 61
Gram-negative bacilli and 21 Gram-positive cocci with 21 different
bacterial species. Antibiotic sensitivity test showed 51% sensitive, 6%
intermediate and 43% resistant. Correlation of leukocyte esterase with
nitrites (p 0.023<0.05), total bacteria count (p 0.00<0.05), Gram
negative bacilli (p 0.00<0.05), and Gram positive cocci (p
0.533>0.05), antibiotic sensitivity test (p 0.794 >0.05) and bacterial
species (p 0.316>0.05). Conclusion : The results showed that there
was a correlation between the level of positivity of leukocyte esterase
and nitrite, total bacteria count and Gram-negative bacilli, but there
was no correlation between Gram-positive cocci, bacterial species and
antibiotic sensitivity tests.