Compliance with Iron Supplementation Consumption in Pregnant Women on Hematological Profiles and Ret-He

Gilang Nugraha, Subagijo Poegoeh Edijanto, Nur Masruroh

Abstract


Fetal growth will increase the mass of maternal and fetal erythrocytes resulting in an increase in iron requirements, causing a decrease in maternal iron stores.A decrease in iron in the body will disrupt the formation of hemoglobin, because one of the components that forms it is heme which contains iron. the aim of our research is to study the compliance of pregnant women in consuming iron supplements regarding hematological features and body iron reserves through the Ret-He examination. This research is a cross-sectional study in 30 pregnant women for complete blood count (CBC), Ret-He and estradiol. There were differences in the concentrations of Hgb and MCHC (P-value < 0.05) and there were no differences in the concentrations of Hct, RBC, MCV, MCH, RDW, Ret-He and estradiol (P-value > 0.05). It was found that there was a relationship between estradiol and Hgb (P-value = 0.047; r = 0.366). Pregnant women who do not comply with taking iron supplements experience a decrease in Hgb and MCHC. The decrease in Hgb levels is strongly correlated with E2 levels in pregnant women who adhere and do not comply with iron supplementation.

Keywords


Pregnant women; Hematological profile; Estradiol

Full Text:

PDF

References


Ahmed, Mostafa H., Mohini S. Ghatge, and Martin K. Safo. 2020. “Hemoglobin: Structure, Function and Allostery.” Sub-Cellular Biochemistry 94:345.

Ems, Thomas, Kayla St Lucia, and Martin R. Huecker. 2023. “Biochemistry, Iron Absorption.” StatPearls.

Farid, Yostina, and Paul Lecat. 2019. Biochemistry, Hemoglobin Synthesis. StatPearls Publishing.

Georgieff, Michael K. 2020. “Iron Deficiency in Pregnancy.” American Journal of Obstetrics and Gynecology 223(4):516–24.

Kong, Weihao, Jun Zheng, Liang Chen, Xiaomin Zuo, Hengyi Wang, Xingyu Wang, Jia Yao, and Wei Chen. 2020. “Mean Corpuscular Hemoglobin Concentration Correlates with Prognosis of Resected Hepatocellular Carcinoma.” Biomarkers in Medicine 14(4):259–71.

Liebmann, Moritz, Melissa Asuaje Pfeifer, Katharina Grupe, and Stephan Scherneck. 2022. “Estradiol (E2) Improves Glucose‐Stimulated Insulin Secretion and Stabilizes GDM Progression in a Prediabetic Mouse Model.” International Journal of Molecular Sciences 23(12).

Nugraha, Gilang. 2017. Panduan Pemeriksaan Laboratorium Hematologi Dasar. Ke-2. Jakarta: Trans Info Media.

Nugraha, Gilang, Nur Masruroh, Prodi Analis Kesehatan, Fakultas Kesehatan, Prodi Kebidanan, Fakultas Keperawatan, and Dan Kebidanan. 2019. “PENGARUH PENINGKATAN LAJU ENDAP DARAH TERHADAP HASIL PEMERIKSAAN FERITIN SERUM PADA IBU HAMIL.” Medical Technology and Public Health Journal 3(2):127–32.

Nugraha, Gilang, Widjiati, Aryati, Citrawati Dyah Kencono Wungu, Harianto Notopuro, Win Darmanto, Agus Sulistyono, Hari Basuki Notobroto, and Purwo Sri Rejeki. 2023. “Lipopolysaccharide-Induced Pregnant Mice Had Decreased Serum Iron While Maintaining Hepcidin Level and Hamp1 MRNA Expression.” Bali Medical Journal 12(2):1881–85.

Pascual, Zoey N., and Michelle D. Langaker. 2023. “Physiology, Pregnancy.” StatPearls.

Pasricha, Sant-Rayn, Jason Tye-Din, Martina U. Muckenthaler, and Dorine W. Swinkels. 2021. “Iron Deficiency.” The Lancet 397(10270):233–48.

Sarma, P. Ravi. 1990. Red Cell Indices. Butterworths.

Sciences, National Academy of Sciences (US) and National Research Council (US) Division of Medical. 1958. “THE ROLE OF IRON IN HEMOGLOBIN SYNTHESIS.”

Takakura, Ikuro, Tomoyuki Kishida, Ryohei Yokoi, and Shinji Souma. 2022. “Estradiol Dominance Induces Hemodilution and Mild Hematological Alterations in Mifepristone-Treated Rats.” The Journal of Toxicological Sciences 47(7):301–8.

Thesen, R., H. Morck, and P. Zagermann. 2022. “Estradiol.” Pharmazeutische Zeitung 132(46):2958–59.

Uçar, Mehmet Ali, Mesude Falay, Simten Dağdas, Funda Ceran, Selin Merih Urlu, and Gülsüm Özet. 2019. “The Importance of RET-He in the Diagnosis of Iron Deficiency and Iron Deficiency Anemia and the Evaluation of Response to Oral Iron Therapy.” Journal of Medical Biochemistry 38(4):496–502.

Warner, Matthew J., and Muhammad T. Kamran. 2017. “Anemia, Iron Deficiency.” StatPearls Publisng. Retrieved (https://www.ncbi.nlm.nih.gov/books/NBK448065/).




DOI: https://doi.org/10.32807/jambs.v11i1.333

Refbacks

  • There are currently no refbacks.


Copyright (c) 2024 Jurnal Analis Medika Biosains (JAMBS)

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

 


Jurnal Analis Medika Biosains (JAMBS) Poltekkes Kemenkes Mataram, Jurusan Analis Kesehatan
Jl. Praburangkasari, Dasan Cermen, Sandubaya, Mataram.

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
slot gacor slot demo slot gacor
slot gacor
slot gacor slot gacor slot gacor slot gacor slot gacor
slot gacor